Dr. Wexner is the Director of the Digestive Disease Center and has been on Staff at Cleveland Clinic Florida since 1988.  He has been the Chairman of the Department of Colorectal Surgery since 1993.  Dr. Wexner was Chief of Staff from 1997-2008, Chief Academic Officer from 2008-2012, and Chairman of the Division of Research and Education from 1995-2012.

Dr. Wexner holds academic appointments as Affiliate Professor at Florida Atlantic University; Clinical Professor at Florida International University; Professor of Surgery at the Ohio State University; Clinical Professor of Surgery at the Cleveland Clinic Lerner College of Medicine of Case Western Reserve University; Affiliate Professor of Surgery at the University of Miami Miller School of Medicine; Professor of Surgery, University of Siena, Siena, Italy; Visiting Professor, Faculty of Medicine, The Hebrew University of Jerusalem, Hadassah Medical Organization, Jerusalem, Israel; and Visiting Professor at the University of Belgrade in Serbia.

In 1999, he was awarded an FRCS from the Royal College of Surgeons in Edinburgh, Scotland and in 2000 he was awarded an FRCS ad eundum from the Royal College of Surgeons in England; and in 2008 by unanimous election of the Council of the Royal College of Surgeons of England, the highest distinction conferred by the Council. In 2015, Dr. Wexner was awarded honorary membership in the European Surgical Association and the European Society of Coloproctology.  In 2013, Dr. Wexner was awarded an honorary foreign membership in the Argentina Society of Coloproctology.

In 2012, Dr. Wexner was awarded the degree of PhD honoris causa by the University of Belgrade. In 2003, The American Jewish Committee presented Dr. Wexner with the prestigious Maimonides Award.  In 2013, he was awarded Professor Emeritus of I.M. Sechenov First Moscow State Medical University.  In 2016, Dr. Wexner was recognized by Cleveland Clinic Florida as a Master Clinician.  In 2017, Dr. Wexner was awarded an honorary membership into the Society of General Surgery of Peru, honorary fellowship in the Royal College of Surgeons in Ireland, and Honorary Clinical Senior Lecturer at the University College London.  On June 5, 2019, Dr. Wexner was award an Honorary Fellowship by the Royal College of Physicians and Surgeons of Glasgow, Scotland.

On October 4, 2019 became a member of the Academy of Master Surgeon Educators of the American College of Surgeons.  In 2018, Dr. Wexner became the chair American College of Surgeons Commission on Cancer National Accreditation Program for Rectal Cancer.  Dr. Wexner is the Past President of the American Society of Colon and Rectal Surgeons Research Foundation (2014-2016), Past President of the American Society of Colon and Rectal Surgeons (2011-2012), Past President of the American Board of Colon and Rectal Surgery (2010-2011), and the Past President of the Society of American Gastrointestinal and Endoscopic Surgeons (2006-2007). Dr. Wexner has served as a Governor to the American College of Surgeons and a member of the Residency Review Committee for Colon and Rectal Surgery.  In 2012, Dr. Wexner was elected as a Regent of the American College of Surgeons and is a member of the Commission on Cancer Executive Committee, as well as chair of the National Accreditation Program for Rectal Cancer.  On a local level, he has also served as the President of the Florida Gastroenterologic Society (2004-2005) and the South Florida Chapter of the American College of Surgeons (2000-2004). Dr. Wexner has also been granted six patents and is a consultant for a variety of commercial entities.

Dr. Wexner was the first surgeon in North America to popularize the colonic J-pouch for rectal cancer.  Due to the study in which he participated and published, that procedure is now an acceptable standard of care for patients with rectal carcinoma. The same is true with his innovations for fecal incontinence and research of laparoscopy for colon and rectal cancer.  In 2020, Dr. Wexner became the Editor-in-Chief of the journal Surgery. Dr. Wexner has published 796 manuscripts, 270 textbook chapters, and 144 editorials and/or invited commentaries.  He is the editor or co-editor of 39 textbooks or freestanding volumes to date and is a member of 56 editorial boards and a reviewer for an additional 40 journals.  He is an active member of 42 learned societies and has held more than 70 appointed or elected offices in these societies.  He is an honorary member of the surgical societies of nine other countries and has held over 70 visiting professorships and delivered over 2,160 scientific lectures.  He has received 17 national, international, and regional awards for his research and is the Symposium Director of the Annual International Colorectal Disease Symposium held in Fort Lauderdale, Florida.  This course is the largest annual international colorectal course in the United States.  In addition, Dr. Wexner trains 15-20 surgeons per year in laparoscopic colorectal surgery, surgical oncology, and the surgical management of inflammatory bowel disease.  In that capacity, he has been the host educator to thousands of surgeons from around the world.

Dr. Wexner has been elected by his peers as one of the best colorectal surgeons for inclusion in The Best Doctors in America (Woodard and White 1995-2012); “The Best Doctors in America”, American Health (1996); “Best Doctors in America (2005-2020)”; “Top Cancer Doctors”, Good Housekeeping Magazine (1999); How to Find the Best Doctors (2000); “Best Doctors in South Florida”, Miami Metro Magazine (2000 and 2001); America’s Top Doctors (Castle Connolly 2002 – 2021); “Guide to America’s Top Surgeons”, Consumer’s Research Council of America (2002-2003, 2006-2012, 2014, 2016); “America’s Top Doctors for Cancer”, Castle Connolly Medical Ltd. (2005 – 2016); “Guide to America’s Top Physicians” 2008; “Executive Health: Top Docs”, South Florida CEO Business Magazine (2002);  Strathmore’s Who’s Who (2006-07; 2008-09); “The Top Docs: 152 Physicians in 30 Specialties in South Florida, Boca Life Magazine (Jun 2007); Top Docs, Boca Life Magazine (2012, 2013, 2015, 2017); 150 Top Docs, Gold Coast Magazine of South Florida (2009-2011); Top Docs of South Florida, Gold Coast Magazine of South Florida (2010, 2012, 2013, 2014, 2017); The Top Docs 250 of the Very Best in 43 Specialties, Gold Coast Fort Lauderdale Magazine (2015, 2016, 2017); “Guide to America’s Top Gastroenterologists” (2007 – 2010); Florida Super Doctors, South Florida Edition of the Miami Herald (2008 – 2009); South Florida Super Doctors, City & Shore Magazine (2012); Presidential Who’s Who, 2011 Edition; Boca Raton Super Doctors 2013; and Best Doctor U.S. News and World Report (2012, 2013); The Top Docs, Gold Coast Magazine (2014, 2019), Newsweek Health: Top Cancer Doctors 2015, Worldwide Leaders in Healthcare 2016, Who’s Who Top Doctors Honors Edition (2017-2018), Top Docs 2020, Fort Lauderdale Illustrated Magazine, and 2021 Top Physicians in Broward County, Fort Lauderdale Illustrated Magazine.