The Hamlyn Symposium on Medical Robotics 2022: 26th-29th June 2022
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Characterisation of microparticle dynamics under thermoplasmonic effect generated by plasmonic optical fibres for bacteria manipulation

In the micro perspective, bacteria swarms is regarded as an ideal drug carrier owing to the autonomy to follow specific gradient around the tumor resulting in the enhanced targeting efficiency [1]. Therefore, manipulation of bacteria swarms towards targeted area is the core for proceeding the research of drug delivery. Some techniques have been proposed, such as optical trapping and magnetic actuation. However, these methods still have limitations as they require high power or strong field, and are only applicable to certain nano/microparticles having specific optical/magnetic properties (e.g. refractive index, permeability, susceptibility, etc.). Plasmonic heating is a strong candidate that can avoid or overcome the abovementioned disadvantages. This study is to demonstrate thermoplasmonic effect on microparticle suspensions using plasmonic optical fibres and to characterise the particle dynamics using image analysis methods for potential applications in enhanced drug delivery.

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