The main goal of brain tumor resection is to achieve complete resection of the tumor with minimal damage to nearby healthy tissues and vasculature. Probe-based Confocal Laser Endomicroscopy(pCLE) has been used to promote the maximum safe resection of brain tumor. However, it is difficult to interpret pCLE images, even for experienced surgeons. The classification of these images is of significance to be studied. The key application of this project is to classify healthy and different types of cancerous brain tumors based on the images of pCLE.